Publications

Peer-reviewed Articles:

1. 1. 1. Letson, J., Furuta, S. Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast. J. Biol. Chem., 2024, 300(12) 108011.
    2. V Sharma, V Fernando, X Zheng, O Sweef, ES Choi, V Thomas, S Furuta. Immunogenic shift of arginine metabolism triggers systemic metabolic and immunological reprogramming to prevent HER2+ breast cancer. bioRxiv, 2024.10. 23.619827 (preprint). PMCID: PMC11527010.
    3. Furuta, S. Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis, Cancers 2024, 16, 3040. PMCID: PMC11394247.
    4. Fernando V, Zheng X, Sharma V, Sweef O, Choi ES, Furuta, S. Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism. Life Sci Alliance 2024 Aug 27;7(11):e202302339. PMC11350068.
    5. Sweef O, Mahfouz R, Taşcıoğlu T, Albowaidey A, Abdelmonem M, Asfar M, Zaabout E, Corcino YL, Thomas V, Choi ES, Furuta S. Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progression. Int J Mol Sci. 2024 Aug 19;25(16). PMC11354875.
    6. Sweef O, Zaabout E, Bakheet A, Halawa M, Gad I, Akela M, Tousson E, Abdelghany A, Furuta, S. Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer. Pharmaceutics. 2023 Jul 31;15(8). PMCID: PMC10459057.
    7. Figy, C.; Guo, A.; Fernando, V.R.; Furuta, S.; Al-Mulla, F.; Yeung, K.C. Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment. Cancers 2023, 15, 958. PMCID: PMC9913418.
    8. Beamer, M., Zamora, C., Kalinoski, A., Veani, F., Sharma, V., Furuta, S. Novel 3D Flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity. Sci. Rep. 2023; 13:870. PMCID: PMC9845379.
    9. Jabbari, K.; Cheng, Q.; Winkelmaier, G.; Furuta, S.; Parvin, B. CD36+ Fibroblasts Secrete Protein Ligands That Growth-Suppress Triple-Negative Breast Cancer Cells While Elevating Adipogenic Markers for a Model of Cancer-Associated Fibroblast. Int. J. Mol. Sci. 2022, 23, 12744. PMCID: PMC9654220
    10. Sharma, V., Letson, J. Furuta, S. Fibrous stroma: passenger or driver in carcinogenesis. Sci. Signal. 2022, 15 (724), eagb3449 (Featured as the Cover Story; Recommended by Faculty Opinions), PMCID: PMC8988932.
    11. Jabbari, K., Winkelmaier, G., Andersen, C., Yaswen, P., Quilici, D., Furuta, S., Cheng, Q., Parvin, B. Protein Ligands in the Secretome of CD36+ Fibroblasts Induce Growth Suppression in a Subset of Breast Cancer Cell Lines. Cancers (Basel) 2021, 13, 4521, PMCID: PMC8469330.
    12. Ren, G., Zheng, X., Sharma, V, Letson, J., Furuta, S. Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts-An Indicator for Breast Carcinogenesis. Cancers (Basel) 2021, 13(11): 2815, PMCID: PMC8201212.
    13. Sharma, V., Fernando,V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., Furuta. S. S–Nitrosylation in Tumor Microenvironment. Int J Mol Sci. 2021, 22(9), 4600, PMCID: PMC8124305.
    14. Zheng, X., Fernando, V., Walia, Y., Sharma, V., Letson, J. and Furuta, S,Correction of Arginine Metabolism with Sepiapterin Induces Immunostimulatory-Shift of Breast Cancer. Biochem Pharmacol 2020; 176:113887, PMCID: PMC7842273.
    15. Ren, G., Sharma, V., Letson, J., Walia, Y., Furuta, S. Reconstituting breast tissue with organotypic three-dimensional co-culture of epithelial and stromal cells in discontinuous extracellular matrices. Bio- protocol 2019; 9(19):e3392. PMCID: PMC7854015.
    16. Fernando, V., Zheng, X., Walia, Y., Sherma, V., Letson, J., Furuta, S. S-nitrosylation: An emerging paradigm of redox signaling. Antioxidants 2019;8(9):pii: E404, PMCID: PMC6769533
    17. Ren, G., Zheng, X., Bommarito, M., Metzger, S., Letson, J., Walia, Y., Furuta, S. Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ. Sci. Rep. 2019; 9(1):6688, PMCID: PMC6491486
    18. Furuta S. (SF also serves as a co-corresponding author with MJB), Ren, G., Mao, J.H., Bissell, M.J. Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs. eLife. 2018; 7: e26148. PMCID: PMC5862529.
    19. Ricca, B.L., Venugopalan, G., Furuta, S., Tanner, K., Orellana, W.A., Reber, C.D., Brownfield, D.G., Bissell, M.J., Fletcher, D.A. Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. eLife. 2018; 7: e26161. PMCID: PMC5862525. (Highly recommended by Faculty 1000.)
    20. Furuta, S. Basal S-nitrosylation is the guardian of tissue homeostasis. Trends in Cancer 2017; 3:744- 748. PMID: 29120749.
    21. Furuta, S. Role of Nitric Oxide (NO) in the Homeostasis of the Normal Breast and Relevance of its Loss to Stiffening of the Extracellular Matrix and Breast Tumor Initiation. J Cancer Oncol. 2017 1(1): 000101.
    22. Furuta, S. Normal Epithelial Cells have Defense Mechanisms against Cancer. Austin Biochem. 2016 1(1): 1005.
    23. Furuta S, Bissell MJ. Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. Cold Spring Harb Symp Quant Biol. 2016; 81:207-217. PMID: 28416576.
    24. Furuta, S., MJ Bissell. Nitric oxide plays a role in transmitting biochemical signal from the extracellular matrix for mammary epithelial morphogenesis. 2014; Mol. Biol. Cell. 5.
    25. Becker-Weimann, S., Xiong, G., Furuta, S., Han, J., Kuhn, I., Akavia, U.D., Pe’er, D., Bissell, M.J., Xu, R. NF-kappaB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget 2013; 4(11):2010-2020. PMCID: PMC3875766.
    26. Lee, S-Y.*, Meier, R.*, Furuta, S.* (*first three contributed equally; SF serves as a co-corresponding author with MJB), Lenburg, M.E., Kenny, P.A., Xu, R., Bissell, M.J. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J. Clin. Invest. 2012; 122(9):3211-3220. PMCID: PMC3428077.
    27. Ordinario, E., Han, H.J., Furuta, S., Heiser, L., Jakkula, L., Rodier, F., Spellman, P., Campisi, J., Gray, J., Bissell, M.J., Kohwi, Y., Kohwi-Shigematsu, T. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLOS One 2012;7(12):e51786. PMCID: PMC3519734.
    28. Furuta, S., Jeng, Y.M., Zhou, L., Huang, L., Kuhn, I., Bissell, M.J., Lee, W.H. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med. 2011; 3(78):78ra31. PMCID: PMC3199022.
    29. Furuta, S., Ghajar, C.M., Bissell, M.J. Caveolin-1: Would-be Achilles’ heel of tumor microenvironment? Cell Cycle 2011; 10:1794-1809. PMID: 22030625.
    30. Jeng, Y.M., Cai, S., Li, A., Furuta, S., Chen, P.L., Lee, E.Y.H.P., Lee, W.H. Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. Oncogene 2007; 24(42):6160-6. PMID: 17420720.
    31. Furuta, S., Wang, J., Shuanzeng, W., Jeng, Y.M., Jiang, X., Gu, B., Chen, P.L., Lee, E.Y.H.P., Lee, W.H. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated breast tumor growth contributed by prominent vasculature. Cancer Cell 2006; 10(11):13-24. PMID: 16843262.
    32. Furuta, S., Jiang, X., Gu, B, Cheng, E., Chen, P.L., Lee, W.H. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005; 102(26):9176-81. PMCID: PMC1166629.
    33. Utomo, A.*, Jiang, X.*, Furuta, S.*, (*first three contributed equally) Yun, J., Levin, D.S., Wang,Y.C., Desai, K.V., Green, J.E., Chen, P.L., Lee, W.H. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem. 2004; 279(42):43522-9. PMID: 15294905.
    34. Furuta, S., Ortiz, F., Zhu, Sun X., Wu, HH., Mason, A., Momand, J. Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. Biochem. J. 2002; 365(Pt 3):639-48. PMCID: PMC1222712
    35. Makmura, L., Hamann, M., Areopagita, A., Furuta, S., Munoz, A., Momand, J. Development of sensitive assay to detect reversibly oxidized protein cysteine sulfhydryl groups. Antioxid. Redox Signal 2001; 3(6):1105-18. PMID: 11813984.

Book Chapters:

Beamer, M., Furuta, S. Redefining cell-culture -- 3D Flipwell co-culture system - a mimetic for Gut Architecture and Dynamics in Vitro. Current Protocol. 2024 (in press)
Sweef, O., Asfar, M., Choi, E-S., Yalitza Lopez Y.C., Thomas, V.D., Albowaidy, A., Furuta, S. From Modification Maps to Clinical Impact: RNA Epigenetics in Cancer Diagnosis and Treatment. 2024, Interdisciplinary Cancer Research .
Choi, E-S., Thomas, V.D., Corcino, Y.L., Sweef, O, Furuta, S.. Exploring the Metabolic Reprogramming of Immune Cells in Tumor Microenvironments. 2024. Interdisciplinary Cancer Research.
Momand, J., Aspuria, P.J., Furuta, S. “MDM2 and MDMX-regulators of p53 activity”, a chapter in Protein Reviews Vol 2: The p53 Tumor Suppressor Pathway and Cancer 2005; pp155-186. Kluwer Academic/Plenum Publishers (New York, NY).